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Prognosis and Survival in Non-Small Cell Lung Cancer: Current Perspectives on NSCLC Life Expectancy and Prognostic Factors

Brightly lit hospital room featuring a middle-aged Hispanic patient in bed, looking hopeful. Beside him, a smiling Hispanic doctor holds a tablet displaying a lung scan image, symbolizing an optimistic and supportive approach to non-small cell lung cancer prognosis, NSCLC life expectancy, and lung cancer survival.

The non-small cell lung cancer (NSCLC) represents one of the leading causes of cancer mortality worldwide. Despite advancements in treatment, the prognosis and survival of patients with NSCLC continue to pose significant challenges. In this context, it is crucial to understand the factors influencing the life expectancy of these patients and the current strategies aimed at improving their outcomes.

Advances in Treatment and Prognostic Factors

In recent years, the treatment of NSCLC has evolved significantly with the introduction of targeted therapies and immunotherapies. These innovations have improved clinical outcomes in patients with specific genetic mutations, allowing for a more personalized approach to treatment. However, the prognosis remains influenced by various factors, such as the presence of chronic lung diseases, which can complicate postoperative management and negatively affect survival (1).

The identification of biomarkers has enabled better prediction of treatment response and prognosis in NSCLC. These markers, along with nodal staging, are crucial for risk stratification and guiding therapeutic decisions (2). Additionally, a family history of cancer may influence disease progression and treatment response, highlighting the importance of considering these backgrounds when assessing a patient's risk profile (3).

Conclusions and Future Perspectives

Despite advancements in the treatment of NSCLC, long-term survival remains a challenge. The integration of survival prediction models, such as the one developed through LASSO regression, offers a valuable tool for risk stratification and personalized patient management (4). Ongoing research into biomarkers and treatment personalization is essential for improving the life expectancy of patients with NSCLC.

Referencias

  1. [1] Surgical outcomes and prognosis of non-small-cell lung cancer in patients with chronic lung diseases: a retrospective analysis.
  2. [2] Role of Pathologic Single-Nodal and Multiple-Nodal Descriptors in Resected Non-Small Cell Lung Cancer.
  3. [3] The impact of family cancer history on tumor metabolism and prognosis in patients with non-small cell lung cancer.
  4. [4] Development and validation of a survival prediction model for patients with advanced non-small cell lung cancer based on LASSO regression.

Created 13/1/2025